Vibrio infections are an increasing global concern and a leading cause of mortality in aquaculture. Conventional treatment with antibiotics has increased antibiotic-resistant bacteria in the environment, posing ecological and health threats. Therefore, it is urgent to find new ways to combat vibriosis. This project tested whether Bdellovibrio and like organisms (BALOs), which are predatory bacteria, could prey on antibiotic-resistant Vibrio and reduce oyster larval mortality. When BALO was applied to treat oyster larvae challenged by pathogenic Vibrio strains, the mortality rates were significantly decreased by up to 73%. This approach functions as a novel treatment for antibiotic-resistant vibriosis in aquaculture, reducing economic loss and protecting coastal resources across the world.