This study explores gene therapy combined with radiotherapy in the CT26 colon cancer mouse model using DRAP - the first integrated platform for drug response analysis on PDX models. A secondary objective was to develop an accessible interface for DRAP, allowing simpler, programming-free, and faster analysis. Gene electrotransfer (GET) was used to deliver plasmids encoding chemokines CCL5 and CCL17 as a monotherapy and with radiotherapy. Two GET protocols were assessed: electrochemotherapy (ECT) and high/low voltage (HV-LV) pulses. DRAP showed that ECT was superior to HV-LV. CCL5 (ECT) with fractionated radiotherapy (3×5Gy) was the most effective. By combining molecular biology and computational analysis, the study offers an interdisciplinary approach vital for advancing cancer research.