Photodynamic therapy (PDT) is a cancer treatment that utilizes light, molecular oxygen, and a photosensitizer (PS) to produce reactive oxygen species. While porphyrins are known PSs, encapsulating them in nanocarriers remains difficult. This is problematic since there is no clinical method for delivering PSs directly into cancer cells. Using ¹H-NMR and ¹H-¹H NOESY spectroscopy, this study shows the encapsulation of mono-TCPP and tetra-TCPP in different nanoparticles. Tetra-TCPP was encapsulated in 87.5% of the nanoparticles, while mono-TCPP was found in 50%, demonstrating the versatility of tetra-TCPP. Although stability requires additional testing, these findings clarify on how to optimize drug delivery for PDT.